Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate

作者：Caroline Andrews, Brian Fortier, Amy Hayward, Ruth Lederman, Lindsay N. Petersen, Jo McBride, Desiree C. Petersen, Olabode Ajayi, Paidamoyo Kachambwa, Moleboheng Seutloali, Aubrey Shoko, Mamokhosana Mokhosi, Reinhard Hiller, Marcia Adams, Chrissie M. Ongaco, Elizabeth Pugh, Jane Romm, Tameka Shelford, Frank Chinegwundoh, Ben Adusei, Sunny Mante, Nana Yaa Snyper, Ilir Agalliu, David W. Lounsbury, Thomas E. Rohan, Alex Orfanos, Yuri Quintana, Judith S. Jacobson, Alfred I. Neugut, Edward P. Gelmann, Joseph Lachance, Chérif Dial, Thierno Diallo, Mohamed Jalloh, Sérigne Maguèye Gueye, Papa Moussa Sène Kane, Halimatou Diop‐Ndiaye, Anna Julienne Selbé Ndiaye, A. Sow, Ndèye Coumba Touré-Kâne, Ezenwa James Onyemata, Alash’le Abimiku, Andrew A. Adjei, Richard Biritwum, Richard K. Gyasi, Mathew Yamoah Kyei, James E. Mensah, Julian Okine, Vicky Okyne, Isabella Rockson, Evelyn Tay, Yao Tettey, Edward D. Yeboah, Wenlong Carl Chen, Elvira Singh, Michael B. Cook, Christine Duffy, Ann W. Hsing, Cassandra Claire Soo, P. Fernandez, Hayley Irusen, Oseremen I. Aisuodionoe-Shadrach, Abubakar Mustapha Jamda, Peter Oluwole Olabode, Maxwell M. Nwegbu, Olalekan Hafees Ajibola, Olushola Ajamu, Yakubu Garba Ambuwa, Akindele O. Adebiyi, Michael C. Asuzu, Olufemi J. Ogunbiyi, Olufemi Popoola, Olayiwola B. Shittu, Olukemi K. Amodu, Emeka Odiaka, Gabriel Ifeoluwa Makinde, Maureen Joffe, Audrey Pentz, Timothy R. Rebbeck · 发表于：Journal of Global Oncology · 年份：2018 · DOI：10.1200/jgo.18.00063 · 被引用次数：28 · 研究领域：Prostate Cancer Diagnosis and Treatment、Prostate Cancer Treatment and Research、Cancer Genomics and Diagnostics

PURPOSE: Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. METHODS: We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. RESULTS: We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across lab...