Antioxidant Properties of Ferulic Acid and Its Possible Application

作者：Kamila Zduńska, Agnieszka Dana, Anna Kołodziejczak, Helena Rotsztejn · 发表于：Skin Pharmacology and Physiology · 年份：2018 · DOI：10.1159/000491755 · 被引用次数：857 · 研究领域：Phytochemicals and Antioxidant Activities、Essential Oils and Antimicrobial Activity、Skin Protection and Aging

Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Ferulic acid has a protective role for the main skin structures: keratinocytes, fibroblasts, collagen, elastin. It inhibits melanogenesis, enhances angiogenesis, and accelerates wound healing. It is widely applied in skin care formulations as a photoprotective agent, delayer of skin photoaging processes, and brightening component. Nonetheless, its use is limited by its tendency to be rapidly oxidized.