Linking gut microbiota, metabolic syndrome and economic status based on a population-level analysis

作者：Yan He, Wei Wu, Shan Wu, Huimin Zheng, Pan Li, Hua-Fang Sheng, Mu-Xuan Chen, Zihui Chen, Guiyuan Ji, Zhongdaixi Zheng, Prabhakar Mujagond, Xiaojiao Chen, Zuhua Rong, Peng Chen, Li-Yi Lyu, Xian Wang, Jiabao Xu, Chong-Bin Wu, Nan Yu, Yanjun Xu, Jia Yin, Jeroen Raes, Wenjun Ma, Hongwei Zhou · 发表于：Microbiome · 年份：2018 · DOI：10.1186/s40168-018-0557-6 · 被引用次数：191 · 研究领域：Gut microbiota and health、Clostridium difficile and Clostridium perfringens research、Oral microbiology and periodontitis research

BACKGROUND: The metabolic syndrome (MetS) epidemic is associated with economic development, lifestyle transition and dysbiosis of gut microbiota, but these associations are rarely studied at the population scale. Here, we utilised the Guangdong Gut Microbiome Project (GGMP), the largest Eastern population-based gut microbiome dataset covering individuals with different economic statuses, to investigate the relationships between the gut microbiome and host physiology, diet, geography, physical activity and socioeconomic status. RESULTS: At the population level, 529 OTUs were significantly associated with MetS. OTUs from Proteobacteria and Firmicutes (other than Ruminococcaceae) were mainly positively associated with MetS, whereas those from Bacteroidetes and Ruminococcaceae were negatively associated with MetS. Two hundred fourteen OTUs were significantly associated with host economic status (140 positive and 74 negative associations), and 157 of these OTUs were also MetS associated. A microbial MetS index was formulated to represent the overall gut dysbiosis of MetS. The values of this index were significantly higher in MetS subjects regardless of their economic status or geographical location. The index values did not increase with increasing personal economic status, although the prevalence of MetS was significantly higher in people of higher economic status. With increased economic status, the study population tended to consume more fruits and vegetables and fewer grains, ...