Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti–Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy

作者：Claas Hinze, Dirk Foell, Anne Johnson, Steven J. Spalding, Beth S. Gottlieb, Paula Morris, Yukiko Kimura, Karen Onel, Suzanne C. Li, Alexei A. Grom, Janalee Taylor, Hermine I. Brunner, Jennifer L. Huggins, James J. Nocton, Kathleen Haines, Barbara Edelheit, Michael Shishov, Lawrence Jung, Calvin B. Williams, Melissa Tesher, D. Costanzo, Lawrence Zemel, Jason Dare, Murray H. Passo, Kaleo Ede, Judyann C. Olson, Elaine Cassidy, Thomas A. Griffin, Linda Wagner‐Weiner, Jennifer E. Weiss, Larry B. Vogler, Kelly Rouster‐Stevens, Timothy Beukelman, Randy Q. Cron, Daniel Kietz, Kenneth N. Schikler, Jay Mehta, Tracy V. Ting, James Verbsky, A. Eberhard, Bin Huang, Edward H. Giannini, Daniel J. Lovell · 发表于：Arthritis & Rheumatology · 年份：2018 · DOI：10.1002/art.40727 · 被引用次数：84 · 研究领域：Autoimmune and Inflammatory Disorders Research、S100 Proteins and Annexins、Rheumatoid Arthritis Research and Therapies

OBJECTIVE: To determine the relationship between serum levels of S100A8/A9 and S100A12 and the maintenance of clinically inactive disease during anti-tumor necrosis factor (anti-TNF) therapy and the occurrence of disease flare following withdrawal of anti-TNF therapy in patients with polyarticular forms of juvenile idiopathic arthritis (JIA). METHODS: In this prospective, multicenter study, 137 patients with polyarticular-course JIA whose disease was clinically inactive while receiving anti-TNF therapy were enrolled. Patients were observed for an initial 6-month phase during which anti-TNF treatment was continued. For those patients who maintained clinically inactive disease over the 6 months, anti-TNF was withdrawn and they were followed up for 8 months to assess for the occurrence of flare. Serum S100 levels were measured at baseline and at the time of anti-TNF withdrawal. Spearman's rank correlation test, Mann-Whitney U test, Kruskal-Wallis test, receiver operating characteristic (ROC) curve, and Kaplan-Meier survival analyses were used to assess the relationship between serum S100 levels and maintenance of clinically inactive disease and occurrence of disease flare after anti-TNF withdrawal. RESULTS: Over the 6-month initial phase with anti-TNF therapy, the disease state reverted from clinically inactive to clinically active in 24 (18%) of the 130 evaluable patients with polyarticular-course JIA; following anti-TNF withdrawal, 39 (37%) of the 106 evaluable patients experi...