Synthesis of Peptide Disulfide-Bond Mimics by Using Fully Orthogonally Protected Diaminodiacids

作者：Tao Wang, Jian Fan, Xiaoxu Chen, Rui Zhao, Yang Xu, Donald Bierer, Lei Liu, Yi‐Ming Li, Jing Shi, Ge‐Min Fang · 发表于：Organic Letters · 年份：2018 · DOI：10.1021/acs.orglett.8b02459 · 被引用次数：29 · 研究领域：Chemical Synthesis and Analysis、Click Chemistry and Applications、Antimicrobial Peptides and Activities

A new strategy was developed for the synthesis of peptide disulfide-bond mimics using fully orthogonally protected diaminodiacids. This method overcomes the previous problems of heavy-metal contamination and poor compatibility with Fmoc chemistry and provides a practical avenue for the efficient preparation of peptide disulfide-bond mimics.