CuS Nanodot-Loaded Thermosensitive Hydrogel for Anticancer Photothermal Therapy

作者：Jijun Fu, Jianye Zhang, Song-pei Li, Lingmin Zhang, Zhongxiao Lin, Lu Liang, Aiping Qin, Xiyong Yu · 发表于：Molecular Pharmaceutics · 年份：2018 · DOI：10.1021/acs.molpharmaceut.8b00624 · 被引用次数：42 · 研究领域：Nanoplatforms for cancer theranostics、Nanoparticle-Based Drug Delivery、Extracellular vesicles in disease

The purpose of this research is to establish an injectable hydrogel encapsulating copper sulfide (CuS) nanodots for photothermal therapy against cancer. The CuS nanodots were prepared by one-pot synthesis, and the thermosensitive Pluronic F127 was used as the hydrogel matrix. The CuS nanodots and the hydrogel were characterized by morphous, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation, and rheology features. The effects of the CuS nanodots and the hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast cancer cells. The retention, photothermal efficacy, therapeutic effects, and systemic toxicity of the hydrogel were assessed in tumor bearing mouse model. The CuS nanodots with a diameter of about 8 nm exhibited satisfying serum stability, photoheat conversion ability, and repeated laser exposure stability. The hydrogel encapsulation did not negatively influence the above features of the photothermal agent. The nanodot-loaded hydrogel shows a phase transition at body temperature and, as a result, a long retention in vivo. The photothermal-agent-embedded hydrogel played a promising photothermal therapeutic effect in the tumor bearing mouse model with low systemic toxicity after peritumoral administration.