Developmental disabilities among children younger than 5 years in 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

作者：Bolajoko Olubukunola Olusanya, Adrian Davis, Donald L. Wertlieb, N Y Boo, M. K. C. Nair, Ricardo Halpern, Hannah Kuper, Cecilia Breinbauer, Petrus J. de Vries, Melissa Gladstone, Neal Halfon, Vijaya Kancherla, Mphelekedzeni C. Mulaudzi, Angelina Kakooza‐Mwesige, Felix Akpojene Ogbo, Jacob Olusegun Olusanya, Andrew Nason Williams, Scott Mitchell Wright, Helena Manguerra, Alison Smith, Michelle Marie Echko, Chad Thomas Ikeda, Angela Liu, Anoushka Millear, Katherine E Ballesteros, Emma L. Nichols, Holly E Erskine, Damian Francesco Santomauro, Zane Rankin, Mari Smith, Harvey Whiteford, Helen Elizabeth Olsen, Nicholas J Kassebaum · 发表于：The Lancet Global Health · 年份：2018 · DOI：10.1016/s2214-109x(18)30309-7 · 被引用次数：740 · 研究领域：Child Nutrition and Water Access、Infant Development and Preterm Care、Cerebral Palsy and Movement Disorders

BACKGROUND: The Sustainable Development Goals (SDGs) mandate systematic monitoring of the health and wellbeing of all children to achieve optimal early childhood development. However, global epidemiological data on children with developmental disabilities are scarce. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 provides a comprehensive assessment of prevalence and years lived with disability (YLDs) for development disabilities among children younger than 5 years in 195 countries and territories from 1990 to 2016. METHODS: We estimated prevalence and YLDs for epilepsy, intellectual disability, hearing loss, vision loss, autism spectrum disorder, and attention deficit hyperactivity disorder. YLDs were estimated as the product of the prevalence estimate and the disability weight for each mutually exclusive disorder, corrected for comorbidity. We used DisMod-MR 2.1, a Bayesian meta-regression tool, on a pool of primary data derived from systematic reviews of the literature, health surveys, hospital and claims databases, cohort studies, and disease-specific registries. FINDINGS: Globally, 52·9 million (95% uncertainty interval [UI] 48·7-57·3; or 8·4% [7·7-9·1]) children younger than 5 years (54% males) had developmental disabilities in 2016 compared with 53·0 million (49·0-57·1; or 8·9% [8·2-9·5]) in 1990. About 95% of these children lived in low-income and middle-income countries. YLDs among these children increased from 3·8 million (95% UI 2·8-4·9) in 199...