Nardochinoids A–C, Three Dimeric Sesquiterpenoids with Specific Fused-Ring Skeletons from Nardostachys chinensis

作者：Xiu‐Yu Shen, Da-Peng Qin, Hua Zhou, Jin-Fang Luo, Yun-Da Yao, Chon-Kit Lio, Haibo Li, Yi Dai, Yang Yu, Xin‐Sheng Yao · 发表于：Organic Letters · 年份：2018 · DOI：10.1021/acs.orglett.8b02511 · 被引用次数：24 · 研究领域：Medicinal Plant Extracts Effects、Phytochemistry and Biological Activities、Plant and Fungal Species Descriptions

Three unusual sesquiterpenoid dimers, nardochinoids A–C ( 1 – 3 ), were isolated from Nardostachys chinensis Batal. Compound 1 features a rare fused 3,8-dioxatricyclo[7.2.1.0 1,6 ]dodecane-11-one ring system, compound 2 is the first nitrogen-containing nornardosinane–aristolane sesquiterpene conjugate, and compound 3 represents the first example of the dimer of a nornardosinane and a nardosinane sesquiterpene. Their structures were characterized by NMR spectroscopic methods and X-ray single-crystal diffraction analysis. Compound 3 showed significant anti-inflammatory activities.