Elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles using trifluoroacetic anhydride as reagent

作者：Beibei Luo, Zhiqiang Weng · 发表于：Chemical Communications · 年份：2018 · DOI：10.1039/c8cc05670f · 被引用次数：62 · 研究领域：Fluorine in Organic Chemistry、Synthesis and Reactions of Organic Compounds、Synthesis and Biological Evaluation

An elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles from the reaction of acetophenone oxime acetates with trifluoroacetic anhydride has been developed. This new tandem cyclization proceeds in good to excellent yields via a SET reduction followed by a 5-endo-trig pathway. Some of the title compounds showed fungicidal and insecticidal activities.