Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling

作者：Mélanie Juilland, Margot Thome · 发表于：Frontiers in Immunology · 年份：2018 · DOI：10.3389/fimmu.2018.01927 · 被引用次数：89 · 研究领域：NF-κB Signaling Pathways、Cell death mechanisms and regulation、Signaling Pathways in Disease

) and CARD9 play major roles in signaling downstream of receptors with immunoreceptor tyrosine activation motifs (ITAMs), G-protein coupled receptors (GPCR) and receptor tyrosine kinases (RTK). These receptors trigger the formation of oligomeric CARMA/CARD-BCL10-MALT1 (CBM) complexes via kinases of the PKC family. The CBM in turn regulates gene expression by the activation of NF-κB and AP-1 transcription factors and controls transcript stability. The paracaspase MALT1 is the only CBM component having an enzymatic (proteolytic) activity and has therefore recently gained attention as a potential drug target. Here we review recent advances in the understanding of the molecular function of the protease MALT1 and summarize how MALT1 scaffold and protease function contribute to the transmission of CBM signals. Finally, we will highlight how dysregulation of MALT1 function can cause pathologies such as immunodeficiency, autoimmunity, psoriasis, and cancer.