Co(II)/Ag(I) Synergistically Catalyzed Monoinsertion Reaction of Isocyanide to Terminal Alkynes with H2O: Synthesis of Alkynamide Derivatives

作者：Rong Zhang, Zheng‐Yang Gu, Shun‐Yi Wang, Shun‐Jun Ji · 发表于：Organic Letters · 年份：2018 · DOI：10.1021/acs.orglett.8b02516 · 被引用次数：30 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Alkyne Reactions、Multicomponent Synthesis of Heterocycles

A Co(II)/Ag(I) synergistically catalyzed three-component reaction of isocyanide with terminal alkyne and water to afford alkynamide derivatives is reported. The insertion of monoisocyanide into the C-H bond of terminal alkynes is an efficient, straightforward, atom-economical route to alkynamides, which are useful synthons in organic synthesis. This synergistic process achieves the cleavage of a C-H bond and the construction of new C-C and C═O bonds under mild conditions through the reaction of Co(II)-activated isocyanides and a Ag(I)-complex-activated terminal alkyne. This reaction has broad substrate versatility and functional group tolerance.