Abstracts of the 5th Central European Forum for Microbiology, October 18-20, 2017, Keszthely, Hungary

作者：Márialigeti, Károly, Dobay, Orsolya · 发表于：Acta Microbiologica et Immunologica Hungarica · 年份：2017 · DOI：10.1556/030.64.2017.102 · 研究领域：Bacterial Identification and Susceptibility Testing、Mycobacterium research and diagnosis

Eukaryotic genomes evolve through accumulation of small-scale changes like point mutations, nucleotide insertions and deletions in their sequences. On the other hand, chromosomal rearrangements (inversions, translocations, fusions and fissions) can also contribute to reshuffling of the gene order. It is widely assumed that there is correlation between nucleotide and structural evolution. However, counterexamples coming from comparative sequence analyses were also revealed. As each genome has their own uniqueness, further investigation of genome evolution can help us to better understand how the different genomes were organized and changed, when and why natural selection acted. The fission yeasts (Schizosaccharomyces) form an ancient clade within the Ascomycete fungi and have a distinct life history from other yeasts. It has been reported that conservation of the gene content within Schizosaccharomyces is significantly higher than that within Saccharomyces or Kluyveromyces. Moreover, gene order and gene structure of the fission yeasts are also more conserved than expected from levels of their amino acid divergences. These observations suggest that fission yeast amino acid sequences evolve anomalously fast or that their genome structures are unusually stable. Thus, stable genome structures of fission yeasts could be consequences of insufficient rearrangements, and because of this the perceived genome conservation is just a remnant of the ancestral gene order. According to anoth...