Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity

作者：Hongjun Huang, Qingqing Xiong, Ning Wang, Ruoyu Chen, Hua Ren, Stefan Siwko, Honghui Han, Mingyao Liu, Min Qian, Bing Du · 发表于：Science Advances · 年份：2018 · DOI：10.1126/sciadv.aas9784 · 被引用次数：40 · 研究领域：Antimicrobial Peptides and Activities、Hypothalamic control of reproductive hormones、Herpesvirus Infections and Treatments

-dependent manner. Thus, our data reveal a kisspeptin/GPR54/calcineurin-mediated immune evasion pathway exploited by virus through the negative feedback loop of TBK1 signaling. These findings also provide insights into the function and cross-talk of kisspeptin, a known neuropeptide hormone, in antiviral innate immune response.