Measurement of cytokines and chemokines and association with clinical severity of dermatomyositis and clinically amyopathic dermatomyositis

作者：M. Chen, Cheng Quan, Lingfeng Diao, F. Xue, Ke Xue, Bo Wang, X. Li, Xiaomei Zhu, Jie Zheng, Hua Cao · 发表于：British Journal of Dermatology · 年份：2018 · DOI：10.1111/bjd.17079 · 被引用次数：49 · 研究领域：Inflammatory Myopathies and Dermatomyositis、Myasthenia Gravis and Thymoma、Systemic Sclerosis and Related Diseases

Dermatomyositis (DM) is an autoimmune disease affecting primarily the skin, muscle and lung. Dysregulations of cytokines and chemokines are commonly found in inflammatory disorders. To investigate the association between serum cytokines and chemokines and clinical severity, especially cutaneous lesions and interstitial lung disease (ILD) in patients with DM and clinically amyopathic DM (CADM). Clinical features, laboratory findings and serum of 40 patients with DM or CADM were collected and analysed. Serum cytokines and chemokines were measured by enzyme‐linked immunosorbent assay or cytometric bead array. A multiple unpaired t‐test was performed to compare cytokines and chemokines in patients with DM and healthy controls. Correlations of serum cytokines and chemokines with disease severity were evaluated by Spearman's rank correlation test. Serum interferon (IFN)‐β [rs = 0·37, 95% confidence interval (CI) 0·078–0·62; P = 0·019] and CXCL10 (rs = 0·32, 95% CI to −0·004 to 0·57; P = 0·045) were significantly correlated with the Cutaneous Dermatomyositis Disease Area and Severity Index activity score in the subset of patients with DM or CADM. Serum levels of interleukin (IL)‐6, IL‐10, IL‐18 and IFN‐β were significantly higher in the patients with acute/subacute interstitial pneumonia (A/SIP) than in the subset without A/SIP (P <0·05). IL‐6 (rs = 0·54, 95% CI 0·27–0·72; P <0·001) and IL‐18 (rs = 0·46, 95% CI 0·21–0·65; P = 0·003) were significantly correlated with the serum level...