Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years

作者：Christopher Troeger, Ibrahim A. Khalil, Puja C Rao, Shujin Cao, Brigette F. Blacker, Tahmeed Ahmed, George Armah, Julie E. Bines, Thomas G. Brewer, Danny V. Colombara, Gagandeep Kang, Beth D. Kirkpatrick, Carl D. Kirkwood, Jason M. Mwenda, Umesh D. Parashar, William A. Petri, Mark S. Riddle, A. Duncan Steele, Robert L. Thompson, Judd L. Walson, John W. Sanders, Ali H. Mokdad, Christopher J L Murray, Simon I Hay, Robert C. Reiner · 发表于：Archives of Pediatrics and Adolescent Medicine · 年份：2018 · DOI：10.1001/jamapediatrics.2018.1960 · 被引用次数：891 · 研究领域：Viral gastroenteritis research and epidemiology、Child Nutrition and Water Access、Respiratory viral infections research

Importance: Rotavirus infection is the global leading cause of diarrhea-associated morbidity and mortality among children younger than 5 years. Objectives: To examine the extent of rotavirus infection among children younger than 5 years by country and the number of deaths averted because of the rotavirus vaccine. Design, Setting, and Participants: This report builds on findings from the Global Burden of Disease Study 2016, a cross-sectional study that measured diarrheal diseases and their etiologic agents. Models were used to estimate burden in data-sparse locations. Exposure: Diarrhea due to rotavirus infection. Main Outcomes and Measures: Rotavirus-associated mortality and morbidity by country and year and averted deaths attributable to the rotavirus vaccine by country. Results: Rotavirus infection was responsible for an estimated 128 500 deaths (95% uncertainty interval [UI], 104 500-155 600) among children younger than 5 years throughout the world in 2016, with 104 733 deaths occurring in sub-Saharan Africa (95% UI, 83 406-128 842). Rotavirus infection was responsible for more than 258 million episodes of diarrhea among children younger than 5 years in 2016 (95% UI, 193 million to 341 million), an incidence of 0.42 cases per child-year (95% UI, 0.30-0.53). Vaccine use is estimated to have averted more than 28 000 deaths (95% UI, 14 600-46 700) among children younger than 5 years, and expanded use of the rotavirus vaccine, particularly in sub-Saharan Africa, could have pre...