PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression

作者：Tian Xie, Shan Pan, Hang Zheng, Zilv Luo, Kingsley M. Tembo, Muhammad Jamal, Zhongyang Yu, Yao Yu, Jing Xia, Qian Yin, Meng Wang, Wen Yuan, Qiuping Zhang, Jie Xiong · 发表于：Cancer Cell International · 年份：2018 · DOI：10.1186/s12935-018-0610-3 · 被引用次数：90 · 研究领域：Ubiquitin and proteasome pathways、Peptidase Inhibition and Analysis、Cancer-related gene regulation

Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 ( PEG10 ), located on human chromosome 7q21.3, has turned out to be an oncogene implicated in the proliferation, apoptosis and metastasis of tumors. PEG10 has been found to be positively expressed in a variety of cancers with seemingly complex expression regulation mechanisms. In this review, we focus on the most vital factors influencing PEG10 expression and recapitulate some of the currently known and potential mechanisms of PEG10 affecting tumor progression, as understanding the molecular regulatory mechanisms of tumor progression can provide potential PEG10 related diagnosis and biomarker specific targeted therapies.