Recent advances in chemical dearomatization of nonactivated arenes

作者：William C. Wertjes, Emma H. Southgate, David Šarlah · 发表于：Chemical Society Reviews · 年份：2018 · DOI：10.1039/c8cs00389k · 被引用次数：532 · 研究领域：Oxidative Organic Chemistry Reactions、Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods

Dearomatization reactions provide a synthetic connection between readily available, simple aromatic starting materials and more saturated intermediates of greater molecular complexity and synthetic utility. The last decade has witnessed a steady increase in the development of dearomative methods, providing new synthetic approaches to high-value building blocks and natural products. This review highlights advances both in the area of dearomatization methodologies for the most chemically inert arenes and in synthetic applications of such strategies.