Topology- and linking number-controlled synthesis of a closed 3 link chain of single-stranded DNA

作者：Qi Li, Guangqi Wu, Yanyan Yang, Ran An, Jing Li, Xingguo Liang, Makoto Komiyama · 发表于：Chemical Communications · 年份：2018 · DOI：10.1039/c8cc04965c · 被引用次数：15 · 研究领域：Advanced biosensing and bioanalysis techniques、DNA and Nucleic Acid Chemistry、RNA Interference and Gene Delivery

In spite of remarkable progress in synthetic methodology, a closed three-link chain (one of the simplest but the most important topological isomers of [3]catenane) has never been prepared. Here we synthesized this isomer in high yield from three oligonucleotides which are designed to optimize various chemical and steric factors in their mutual hybridization.