Overexpression of MAPT-AS1 is associated with better patient survival in breast cancer

作者：Dongfeng Wang, Jian Li, Fengling Cai, Zhi Xu, Li Li, Huanfeng Zhu, Wei Liu, Qingyu Xu, Jian Cao, Jingfeng Sun, Jinhai Tang · 发表于：Biochemistry and Cell Biology · 年份：2018 · DOI：10.1139/bcb-2018-0039 · 被引用次数：33 · 研究领域：Cancer-related molecular mechanisms research、RNA regulation and disease、RNA Research and Splicing

Breast cancer is the most frequent malignant disease in women worldwide. It is a heterogeneous and complex genetic disease with different molecular characteristics. MAPT-AS1, a long non-coding RNA (lncRNA) existing at the anti-sense strand of the MAPT (microtubule associated protein tau) promoter region, was believed to regulate MAPT, which was associated with disease state in Parkinson's disease. But the role of MAPT-AS1 in breast cancer has never been reported. In our study we found that MAPT-AS1 is overexpressed in breast cancer but not in triple negative breast cancer (TNBC), and that high expression of MAPT-AS1 was correlated with better patient survival. In addition, the level of MAPT-AS1 was correlated with the expression of MAPT, and MAPT was associated with survival time in breast cancer. Our study suggests that MAPT-AS1 may play a role and be a potential survival predictive biomarker in breast cancer.