Amantadine Surface-Modified Silver Nanorods Improves Immunotherapy of HIV Vaccine Against HIV-Infected Cells

作者：Weiyu Li, Yekkuni L. Balachandran, Yanling Hao, Xie Hao, Runzhi Li, Zhangjie Nan, Hongying Zhang, Yiming Shao, Ye Liu · 发表于：ACS Applied Materials & Interfaces · 年份：2018 · DOI：10.1021/acsami.8b10948 · 被引用次数：15 · 研究领域：Advanced biosensing and bioanalysis techniques、HIV Research and Treatment、COVID-19 Impact on Reproduction

Surface modifications can endow nanomaterials with presupposed immunoregulatory functions to optimize vaccine-induced immune responses. In this work, we modified an immunoregulatory molecule, amantadine (Ada), on the outermost layer of PVP-PEG-coated silver nanorods (Ada-PVP-PEG silver nanorods). Such Ada surface-modified silver nanorods promote HIV vaccine-triggered cytotoxic lymphocytes (CTLs) to produce around eightfold stronger tumor necrosis factor alpha (TNF-α) in vivo. The enhancement of HIV-specific CTL-derived TNF-α significantly facilitates the death of HIV-infected cells (from 28.86 to 84.19%) and reduces HIV production (around sixfold). This work supports the critical role of surface modifications of nanomaterials in fundamentally improving the immunotherapy of HIV vaccine against HIV-infected cells.