Factors relevant to atrial 18F-fluorodeoxyglucose uptake in atrial fibrillation

作者：Boqia Xie, Bi-Xi Chen, Jiaoyan Wu, Xingpeng Liu, Min-Fu Yang · 发表于：Journal of Nuclear Cardiology · 年份：2018 · DOI：10.1007/s12350-018-1387-4 · 被引用次数：34 · 研究领域：Cardiovascular Disease and Adiposity、Cardiac Imaging and Diagnostics、Atrial Fibrillation Management and Outcomes

Background This retrospective study was designed to explore the factors relevant to increased atrial 18 F-fluorodeoxyglucose (FDG) uptake in patients with atrial fibrillation (AF) who had undergone routine whole-body positron emission tomography/computed tomography (PET/CT) imaging. Methods and Results Forty-eight consecutive AF patients (32 persistent, 16 paroxysmal) were identified from our routine FDG PET/CT database. Twenty-two control subjects were selected to establish the normal range of FDG uptake (maximum standardized uptake value, SUV max ) in target tissues. A target-to-background ratio (TBR) was calculated to determine abnormal uptake in the atrium and atrial appendage (AA). Univariate comparisons and multivariate regression analyses were conducted to explore the factors associated with the increased FDG accumulation in the atrium and AA. Seventeen AF patients, all with persistent AF, had increased atrial FDG uptake. Most of them (14, or 82.4%) had increased uptake in the right atrium. Eleven AF patients, 9 with persistent AF, had increased uptake in the AA, and bilateral AAs were equally involved. Multivariate logistic regression analyses identified that female gender, persistent AF, and activity in epicardial adipose tissue (EAT) were independent factors predicting the increased activity of the atrium; also, SUV max of the left ventricle was found for the AA. In addition, multivariate linear regression analyses showed that EAT activity was the only independent v...