Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

作者：Mary Kate Alexander, Anh Miu, Angela Oh, Mike Reichelt, Hoangdung Ho, Cécile Chalouni, Sharada S. Labadie, Lan Wang, Jun Liang, Nicholas N. Nickerson, Huiyong Hu, Yu Lan, Miaofen Du, Donghong Yan, Summer Park, Janice Kim, Min Xu, Benjamin D. Sellers, Hans E. Purkey, Nicholas J. Skelton, Michael F. T. Koehler, Jian Payandeh, Vishal Verma, Yiming Xu, Christopher M. Koth, Mireille Nishiyama · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2018 · DOI：10.1128/aac.01142-18 · 被引用次数：76 · 研究领域：Antibiotic Resistance in Bacteria、Bacterial Genetics and Biotechnology、Probiotics and Fermented Foods

through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains. Identification of these selective inhibitors indicates that MsbA is a viable target for new antibiotics, and the compounds we identified serve as useful tools to further probe the LPS transport pathway in Gram-negative bacteria.