Dietary Sodium Intake and Serum Uric Acid: A Mini-Review

作者：Lei Lei, Ji‐Guang Wang · 发表于：Pulse · 年份：2018 · DOI：10.1159/000490573 · 被引用次数：10 · 研究领域：Gout, Hyperuricemia, Uric Acid、Liver Disease Diagnosis and Treatment、Diet, Metabolism, and Disease

The aim of the present review is to summarize recent studies on the relationship between dietary sodium intake and serum uric acid concentration. In short-term dietary sodium intervention studies, including a recent further analysis of a previously published trial, high dietary sodium intake (200 mmol/day), compared with a low sodium diet (20-60 mmol/day), resulted in a significant reduction in serum uric acid, being approximately 20-60 μmol/L. This finding, though consistent across short-term studies, is in contradiction to the long-term observational evidence on the relationship between dietary sodium intake and serum uric acid. Indeed, in a population-based prospective study, high dietary sodium intake was associated with a higher serum uric acid concentration. If serum uric acid would be followed up, several currently ongoing long-term randomized dietary sodium intervention studies may shed some light on how dietary sodium intake interacts with serum uric acid in the development of hypertension.