Effect of fermented Cordyceps�sinensis on doxorubicin‑induced cardiotoxicity in rats

作者：Rong Wu, Ping‐An Yao, Huilin Wang, Yan Gao, Hai‐Lun Yu, Lei Wang, Xiaohua Cui, Xu Xu, Jianping Gao · 发表于：Molecular Medicine Reports · 年份：2018 · DOI：10.3892/mmr.2018.9310 · 被引用次数：29 · 研究领域：Cancer-related cognitive impairment studies、Cancer Treatment and Pharmacology、Fungal Biology and Applications

Cordyceps sinensis (CS) is a prominent medicinal herb in traditional Chinese medicine, and fermented CS is frequently used as a substitute for natural CS. Doxorubicin (DOX), an antitumor drug used in chemotherapy, is limited by its poor cardiotoxicity. The aim of the present study was to evaluate the protective effect of fermented CS against DOX‑induced cardiotoxicity and the potential underlying mechanisms. Male Sprague‑Dawley rats (180‑200 g) were randomly assigned to seven different treatment groups: Normal control, DOX control, DOX+captopril (0.05 g/kg), 0.75, 1.5 and 3 g/kg DOX+CS, and the CS (1.5 g/kg) control. Histopathological changes, cardiac energy metabolism, cyclic adenosine monophosphate (cAMP) signaling and the associated mRNA expression of AMP‑activated protein kinase (AMPK) were then evaluated. Fermented CS decreased the left ventricular weight index, heart weight index and mortality; however, it increased diastolic blood pressure and mean arterial pressure. In addition, it shortened the duration of the QRS complex and Sα‑T segment, decreased serum creatine kinase (CK) and aspartate aminotransferase activity, inhibited histopathological changes and reduced brain natriuretic peptide content. Treatment with fermented CS also increased the activities of superoxide dismutase and glutathione peroxidase, reduced malondialdehyde content, increased the mitochondrial activities of Na+K+‑adenosine 5'‑triphosphate (ATP) ase, Ca2+Mg2+‑ATPase and CK, and increased the crea...