A combined study of 18F‑FDG PET‑CT and fMRI for assessing resting cerebral function in patients with major depressive disorder

作者：Chang Fu, Hongju Zhang, Ang Xuan, Yongju Gao, Junling Xu, Dapeng Shi · 发表于：Experimental and Therapeutic Medicine · 年份：2018 · DOI：10.3892/etm.2018.6434 · 被引用次数：29 · 研究领域：Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications、Medical Imaging Techniques and Applications

The present study investigated changes in the regional cerebral metabolic rates of glucose uptake (rCMRglc) using 18F‑fluorodeoxyglucose (18F‑FDG) positron emission tomography (PET) and regional homogeneity (ReHo), together with resting‑state blood oxygen level‑dependent (BOLD) functional magnetic resonance imaging (fMRI), in patients with major depressive disorder (MDD). In total, 18 patients with untreated MDD and 17 healthy control subjects underwent 18F‑FDG PET and BOLD‑fMRI scanning. The MDD patients' cerebral changes, measured as rCMRglc and ReHo values, were mapped and statistically analyzed. Compared with the control group, the patients with MDD had a decreased rCMRglc in the bilateral superior, middle and inferior frontal gyrus, in the bilateral superior and middle temporal gyrus, in the bilateral anterior cingulate cortex, in the bilateral putamen and caudate, and in the left pallidum, but an increased rCMRglc in the bilateral hippocampus and left thalamus. The ReHo values in the patient group were decreased in the bilateral superior and middle frontal gyrus, left pallidum, bilateral putamen and left anterior cingulate cortex, but increased in the right hippocampus and thalamus. No statistically significant differences were identified between decreased metabolism and ReHo brain regions of MDD patients (χ2=9.16; P=0.90) and between increased metabolism and ReHo brain regions (χ2=3.96; P=0.27), when comparing activated brain regions of PET and MRI. The standardized up...