Chimeric Antigen Receptor Therapy

作者：Carl H. June, Michel Sadelain · 发表于：New England Journal of Medicine · 年份：2018 · DOI：10.1056/nejmra1706169 · 被引用次数：2365 · 研究领域：CAR-T cell therapy research、Biomedical Ethics and Regulation、Cancer Immunotherapy and Biomarkers

Interview with Dr. Carl June on chimeric antigen receptor therapy. (09:04)Download This review addresses T-cell engineering and synthetic immunity, with a focus on producing durable remissions in patients with treatment-refractory tumors. Toxic effects of chimeric antigen receptor therapies include cytokine release syndrome and neurologic dysfunction.