Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

作者：David W. Eyre, Nicholas D. Sanderson, Emily Lord, Natasha Regisford-Reimmer, Kevin Chau, Leanne Barker, Markus Morgan, Robert Newnham, Daniel Golparian, Magnus Unemo, Derrick W. Crook, Tim Peto, Gwenda Hughes, Michelle Cole, Helen Fifer, Anne Edwards, Monique Andersson · 发表于：Eurosurveillance · 年份：2018 · DOI：10.2807/1560-7917.es.2018.23.27.1800323 · 被引用次数：379 · 研究领域：Reproductive tract infections research、Adolescent Sexual and Reproductive Health、Syphilis Diagnosis and Treatment

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.