Validity and Clinically Meaningful Changes in the Psychosexual Daily Questionnaire and Derogatis Interview for Sexual Function Assessment: Results From the Testosterone Trials

作者：Christina Wang, Alisa J. Stephens‐Shields, Leonard R. Derogatis, Glenn R. Cunningham, Ronald S. Swerdloff, Peter Preston, David Cella, Peter J. Snyder, Thomas M. Gill, Shalender Bhasin, Alvin M. Matsumoto, Raymond C. Rosen · 发表于：The Journal of Sexual Medicine · 年份：2018 · DOI：10.1016/j.jsxm.2018.05.008 · 被引用次数：17 · 研究领域：Sexual function and dysfunction studies、Hormonal and reproductive studies、Menopause: Health Impacts and Treatments

BACKGROUND: Limited information is available on the performance characteristics of 2 questionnaires commonly used in clinical research, the Psychosexual Daily Questionnaire (PDQ) and the Derogatis Interview for Sexual Function (DISF)-II Assessment, especially in older men with low testosterone (T) and impaired sexual function. AIM: To determine reliability of PDQ and DISF-II by assessing the correlation within and between domains in the questionnaires and to define clinically meaningful changes in sexual activity (PDQ question 4 [Q4]) and desire (DISF-II sexual desire domain [SDD]) domains. METHODS: Data from 470 men participating in the T Trials were used to calculate Spearman correlation coefficients of individual items and total score among questionnaires to determine convergent and construct validity. Clinically meaningful changes for sexual desire and activity were determined by randomly dividing the sample into training and validation sets. Anchor- and distribution-based clinically meaningful change criteria were defined in the training set, and selected changes were evaluated in the validation set. OUTCOMES: Validity of the PDQ and DISF-II and clinically meaningful changes in sexual desire and activity were determined in older men in T Trials. RESULTS: Moderate to strong correlations were shown within and between domains from different questionnaires. Using Patient Global Impression of Change as an anchor, clinically meaningful change in PDQ sexual activity was ≥0.6, a...