Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)

作者：Moses K. Langat, Andreas Helfenstein, Claire Horner, Päivi Tammela, Heikki Hokkanen, Denis Izotov, Dulcie A. Mulholland · 发表于：Chemistry & Biodiversity · 年份：2018 · DOI：10.1002/cbdv.201800056 · 被引用次数：16 · 研究领域：Biological Activity of Diterpenoids and Biflavonoids、Natural product bioactivities and synthesis、Sesquiterpenes and Asteraceae Studies

Pumilol ( 1 ), a strobane diterpenoid, reported herein for the first time, was isolated from the bark of Pinus pumila ( Pall .) Regel (Siberian Dwarf Pine or Japanese Stone Pine), along with 17 known compounds including serratane triterpenoids, not previously reported from this species, and four ferulate derivatives. The absolute configuration of pumilol was established using HR ‐ ESI ‐ MS , NMR , the DP 4+ probabilities and by comparison of the experimental and calculated electronic circular dichroism ( ECD ) spectra. Labda‐8(17),13‐dien‐15‐oic acid ( 4 ), bornyl ( E )‐4‐hydroxycinnamate ( 14 ) and bornyl ( E )‐ferulate ( 15 ) showed activity against S . aureus and/or E . faecalis with MIC 90 values 12.5 – 50 μ m .