Analysis of miRNA Expression Profiling Identifies miR-214-3p as a Novel Biomarker in Sinonasal Inverted Papilloma

作者：Yaoshu Teng, Yuandong Li, Zhihong Lin, Yueqiu Gao, Xiaolin Cao, Xiangyu Lou, Fengchun Lin, Yong Li · 发表于：Epigenomics · 年份：2018 · DOI：10.2217/epi-2018-0071 · 被引用次数：14 · 研究领域：Head and Neck Surgical Oncology、Sinusitis and nasal conditions、Congenital Ear and Nasal Anomalies

AIM: To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP). MATERIALS & METHODS: The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods. RESULTS: The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence. CONCLUSION: MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP.