Social networks and symptomatic and functional outcomes in schizophrenia: a systematic review and meta-analysis

作者：Amy Degnan, Katherine Berry, Daryl Sweet, Kathryn Mary Abel, Nick Crossley, Dawn Edge · 发表于：Social Psychiatry and Psychiatric Epidemiology · 年份：2018 · DOI：10.1007/s00127-018-1552-8 · 被引用次数：199 · 研究领域：Mental Health Research Topics、Schizophrenia research and treatment、Functional Brain Connectivity Studies

To conduct a systematic review and meta-analysis to examine the strength of associations between social network size and clinical and functional outcomes in schizophrenia. Studies were identified from a systematic search of electronic databases (EMBASE, Medline, PsycINFO, and Web of Science) from January 1970 to June 2016. Eligible studies included peer-reviewed English language articles that examined associations between a quantitative measure of network size and symptomatic and/or functional outcome in schizophrenia-spectrum diagnoses. Our search yielded 16 studies with 1,929 participants. Meta-analyses using random effects models to calculate pooled effect sizes (Hedge’s g ) found that smaller social network size was moderately associated with more severe overall psychiatric symptoms ( N = 5, n = 467, g = − 0.53, 95% confidence interval (CI) = − 0.875, − 0.184, p = 0.003) and negative symptoms ( N = 8, n = 577, g = − 0.75, 95% CI = − 0.997, − 0.512, p = 0.000). Statistical heterogeneity was observed I 2 = 63.04%; I 2 = 35.75%,) which could not be explained by low-quality network measures or sample heterogeneity in sensitivity analyses. There was no effect for positive symptoms ( N = 7, n = 405, g = − 0.19, 95% CI = 0.494, 0.110, p = 0.213) or social functioning ( N = 3, n = 209, g = 0.36, 95% CI = − 0.078, 0.801, p = 0.107). Narrative synthesis suggested that larger network size was associated with improved global functioning, but findings for affective symptoms and qualit...