Methods for 2-Deoxyglycoside Synthesis

作者：Clay S. Bennett, M. Carmen Galán · 发表于：Chemical Reviews · 年份：2018 · DOI：10.1021/acs.chemrev.7b00731 · 被引用次数：365 · 研究领域：Carbohydrate Chemistry and Synthesis、Enzyme Catalysis and Immobilization、Glycosylation and Glycoproteins Research

Deoxy-sugars often play a critical role in modulating the potency of many bioactive natural products. Accordingly, there has been sustained interest in methods for their synthesis over the past several decades. The focus of much of this work has been on developing new glycosylation reactions that permit the mild and selective construction of deoxyglycosides. This Review covers classical approaches to deoxyglycoside synthesis, as well as more recently developed chemistry that aims to control the selectivity of the reaction through rational design of the promoter. Where relevant, the application of this chemistry to natural product synthesis will also be described.