The NHLBI LAM Registry

作者：Nishant Gupta, Hye‐Seung Lee, Jay H. Ryu, Angelo M. Taveira‐DaSilva, Gerald J. Beck, Jar-Chi Lee, Kevin McCarthy, Geraldine A. Finlay, Kevin K. Brown, Stephen J. Ruoss, Nilo A. Avila, Joel Moss, Francis X. McCormack · 发表于：CHEST Journal · 年份：2018 · DOI：10.1016/j.chest.2018.06.016 · 被引用次数：109 · 研究领域：Tuberous Sclerosis Complex Research、Vascular Tumors and Angiosarcomas、Soft tissue tumors and treatment

Background The natural history of lymphangioleiomyomatosis (LAM) is mainly derived from retrospective cohort analyses, and it remains incompletely understood. A National Institutes of Health LAM Registry was established to define the natural history and identify prognostic biomarkers that can help guide management and decision-making in patients with LAM. Methods A linear mixed effects model was used to compute the rate of decline of FEV 1 and to identify variables affecting FEV 1 decline among 217 registry patients who enrolled from 1998 to 2001. Prognostic variables associated with progression to death/lung transplantation were identified by using a Cox proportional hazards model. Results Mean annual decline of FEV 1 was 89 ± 53 mL/year and remained remarkably constant regardless of baseline lung function. FEV 1 decline was more rapid in those with greater cyst profusion on CT scanning ( P = .02) and in premenopausal subjects (118 mL/year) compared with postmenopausal subjects (74 mL/year) ( P = .003). There were 26 deaths and 43 lung transplantations during the evaluation period. The estimated 5-, 10-, 15-, and 20-year transplant-free survival rates were 94%, 85%, 75%, and 64%, respectively. Postmenopausal status (hazard ratio, 0.30; P = .0002) and higher baseline FEV 1 (hazard ratio, 0.97; P = .008) or diffusion capacity of lung for carbon monoxide (hazard ratio, 0.97; P = .001) were independently associated with a lower risk of progression to death or lung transplantatio...