A Linear Plasmid-Like Prophage of Actinomyces odontolyticus Promotes Biofilm Assembly

作者：Mengyu Shen, Yuhui Yang, Wei Shen, Lujia Cen, Jeffrey S. McLean, Wenyuan Shi, Shuai Le, Xuesong He · 发表于：Applied and Environmental Microbiology · 年份：2018 · DOI：10.1128/aem.01263-18 · 被引用次数：33 · 研究领域：Bacteriophages and microbial interactions、Genomics and Phylogenetic Studies、Microbial infections and disease research

The biology of phages as members of the human oral microbiome is understudied. Here, we report the characterization of xhp1, a novel linear plasmid-like prophage identified from a human oral isolate, Actinomyces odontolyticus subsp. actinosynbacter strain XH001. xhp1 can be induced and reinfect xhp1-cured XH001. The spontaneous induction of xhp1 leads to the lysis of a subpopulation of bacterial hosts and the release of eDNA that promotes biofilm assembly, thus potentially contributing to the persistence of A. odontolyticus within the oral cavity.