Effect of age on the morphologies of the human Schlemm’s canal and trabecular meshwork measured with swept‑source optical coherence tomography

作者：Zhiqi Chen, Jian Sun, Mu Li, Shiliang Liu, Liugui Chen, Si-li Jing, Zhen Cai, Yan Xiang, Yinwei Song, Hong Zhang, Junming Wang · 发表于：Eye · 年份：2018 · DOI：10.1038/s41433-018-0148-6 · 被引用次数：61 · 研究领域：Glaucoma and retinal disorders、Corneal surgery and disorders、Retinal and Macular Surgery

PURPOSE: We aimed to measure the sizes of Schlemm's canal (SC) and the trabecular meshwork (TM) in healthy individuals and to evaluate variations with age from childhood to old age by using swept-source optical coherence tomography (OCT). METHODS: Anterior chamber angle imaging of the superior, inferior, nasal, and temporal regions of the right and left eyes was performed with swept-source OCT. The diameter and area of SC and TM width and thickness were measured manually from OCT images. RESULTS: A total of 114 healthy individuals were enrolled and included 48 male subjects and 66 female subjects; their ages ranged from 7 to 83 years. Both the SC diameter and area in the four quadrants decreased significantly with aging (P < 0.001) and were wider in the nasal and temporal quadrants compared with the superior and inferior quadrants. Changes in SC size showed significant positive correlations with axial length (AL) and anterior chamber depth (P < 0.001). There was a significant positive association between age and TM thickness in the nasal and temporal quadrants (P < 0.05). The inferior quadrant TM width was the widest among the quadrants. The superior quadrant TM thickness was the thinnest among the quadrants. Changes in TM thickness in the nasal and temporal quadrants showed a significant negative correlation with AL (P < 0.05). There was no statistically significant correlation in SC and TM parameters with central corneal thickness, intraocular pressure, sex, or right or lef...