Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster

作者：Jun Young Sonn, Jongbin Lee, Min Kyung Sung, Hwajung Ri, Jung Kyoon Choi, Chunghun Lim, Joonho Choe · 发表于：Proceedings of the National Academy of Sciences · 年份：2018 · DOI：10.1073/pnas.1719033115 · 被引用次数：37 · 研究领域：Circadian rhythm and melatonin、Neurobiology and Insect Physiology Research、Genetics, Aging, and Longevity in Model Organisms

Significance Foraging and sleep are two conflicting behaviors in starved animals; however, it remains elusive how metabolic status governs sleep drive. In this study, we show that a biosynthetic pathway for the amino acid serine is transcriptionally up-regulated by starvation in adult fly brains. The behavioral response to genetic manipulation of key enzymes involved in serine metabolism supports the sleep-suppressing effect of serine in response to starvation. In a society where daily diet is becoming increasingly important to the sleep quality of individuals, our study defines an amino acid metabolic pathway that underlies adaptive sleep behaviors upon dietary stress.