Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

作者：Gregory L. Beutner, Ronald Carrasquillo‐Flores, Peng Geng, Yi Hsiao, Eric C. Huang, Jacob M. Janey, Kishta Katipally, Sergei Kolotuchin, Thomas La Porte, Andrew Lee, Paul C. Lobben, Federico Lora Gonzalez, Brendan Mack, Boguslaw Mudryk, Yuping Qiu, Xinhua Qian, Antonio Ramı́rez, Thomas M. Razler, Thorsten Rosner, Zhongping Shi, Eric M. Simmons, Jason M. Stevens, Jianji Wang, Carolyn S. Wei, Steven R. Wisniewski, Ye Zhu · 发表于：Organic Letters · 年份：2018 · DOI：10.1021/acs.orglett.8b01218 · 被引用次数：60 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Molecular spectroscopy and chirality、Chemical synthesis and alkaloids

High Resolution Image Download MS PowerPoint Slide A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.