ERα-mediated cell cycle progression is an important requisite for CDK4/6 inhibitor response in HR+ breast cancer

作者：Karineh Petrossian, Noriko Kanaya, Chiao Lo, Pei-Yin Hsu, Duc Minh Nguyen, Lixin Yang, Lu Yang, Charles Warden, Xiwei Wu, Raju K. Pillai, Lauren Bernal, Chiun‐Sheng Huang, Laura L. Kruper, Yuan Yuan, George Somlo, Joanne E. Mortimer, Shiuan Chen · 发表于：Oncotarget · 年份：2018 · DOI：10.18632/oncotarget.25552 · 被引用次数：20 · 研究领域：Advanced Breast Cancer Therapies、Cancer-related Molecular Pathways、Retinoids in leukemia and cellular processes

// Karineh Petrossian 1 , Noriko Kanaya 1 , Chiao Lo 2 , Pei-Yin Hsu 1 , Duc Nguyen 1 , Lixin Yang 3 , Lu Yang 4 , Charles Warden 4 , Xiwei Wu 4 , Raju Pillai 3 , Lauren Bernal 1 , Chiun-Sheng Huang 2 , Laura Kruper 5 , Yuan Yuan 6 , George Somlo 6 , Joanne Mortimer 6 and Shiuan Chen 1 1 Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA, United States 2 Department of Breast Health, National Taiwan University Hospital, Taipei City, Taiwan 3 Molecular Pathology Core, Beckman Research Institute of the City of Hope, Duarte, CA, United States 4 Integrative Genomics Core, Beckman Research Institute of the City of Hope, Duarte, CA, United States 5 Department of Surgery, City of Hope Medical Center, Duarte, CA, United States 6 Department of Medical Oncology and Therapeutics Research, City of Hope Medical Center, Duarte, CA, United States Correspondence to: Shiuan Chen, email: schen@coh.org Keywords: CDK4/6 inhibitors; palbociclib; patient-derived xenografts (PDX); single cell analysis; DEPArray Received: January 04, 2018 Accepted: May 19, 2018 Published: June 12, 2018 ABSTRACT While ER has multiple biological effects, ER-cyclin D1-CDK4/6-RB is a critical pathway for the action of estrogen on the cell cycle, especially for breast cancers that rely on estrogen for growth. The latest and most efficient CDK4/6 inhibitors target the phosphorylation of retinoblastoma (RB) tumor suppressor gene; thus, altering levels of many cell cycle molecules. Estro...