Recognizing Depression from the Microbiota–Gut–Brain Axis

作者：Shan Liang, Xiaoli Wu, Xu Hu, Tao Wang, Feng Jin · 发表于：International Journal of Molecular Sciences · 年份：2018 · DOI：10.3390/ijms19061592 · 被引用次数：382 · 研究领域：Tryptophan and brain disorders、Gut microbiota and health、Neuroendocrine regulation and behavior

Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain⁻gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota⁻gut⁻brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression. Nowadays, the gut microbiota modulation has become a hot topic in treatment research of mental disorders. Depression is closely related with the health condition of the brain⁻gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders.