Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis

作者：Yanping Jiang, Karolina Dukik, José Fernando Muñoz, Lynne Sigler, Ilan Steven Schwartz, Nelesh Premapragasan Govender, Chris Richard Kenyon, Peiying Feng, Bert Gerrits van den Ende, J. Benjamin Stielow, Alberto Miguel Stchigel, Hongguang Lü, Sybren de Hoog · 发表于：Fungal Diversity · 年份：2018 · DOI：10.1007/s13225-018-0403-y · 被引用次数：116 · 研究领域：Fungal Infections and Studies、Plant Pathogens and Fungal Diseases、Plant Pathogens and Resistance

The family Ajellomycetaceae (Onygenales) includes mammal-associated pathogens within the genera Blastomyces , Emmonsia , Histoplasma and Paracoccidioides , as well as the recently described genera, Emergomyces that causes disease in immunocompromised hosts, and Emmonsiellopsis, known only from soil. To further assess the phylogenetic relationships among and between members of these genera and several previously undescribed species, we sequenced and analyzed the DNA-directed RNA polymerase II ( rPB 2), translation elongation factor 3-α ( TEF3 ), β-tubulin ( TUB2 ), 28S large subunit rDNA (LSU) and the internal transcribed spacer regions (ITS) in 68 strains, in addition to morphological and physiological investigations. To better understand the thermal dimorphism among these fungi, the dynamic process of transformation from mycelial to yeast-like or adiaspore-like forms was also assessed over a range of temperatures (6–42 °C). Molecular data resolved the relationships and recognized five major well-supported lineages that correspond largely to the genus level. Emmonsia , typified by Emmonsia parva , is a synonym of Blastomyces that also accommodates Blastomyces helicus (formerly Emmonsia helica ). Emmonsia crescens is phylogenetically distinct, and found closely related to a single strain from soil without known etiology. Blastomyces silverae , Emergomyces canadensis , Emergomyces europaeus and Emmonsia sola are newly described. Almost all of the taxa are associated with human ...