Endothelial progenitor cells in age-related vascular remodeling

作者：Jinxiu Yang, Yanyun Pan, Xingxiang Wang, Yuangang Qiu, Wei Mao · 发表于：Cell Transplantation · 年份：2018 · DOI：10.1177/0963689718779345 · 被引用次数：60 · 研究领域：Angiogenesis and VEGF in Cancer、Inflammatory Biomarkers in Disease Prognosis、Pregnancy and preeclampsia studies

Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved in the pathogenesis of age-related vascular remodeling. This review is presented to summarize the characteristics of EPCs and age-related vascular remodeling. In addition, the role of EPCs in age-related vascular remodeling and possible solutions for improving the therapeutic effects of EPCs in the treatment of age-related diseases are discussed.