Self [3 + 4] Cycloadditions of Isatin N , N ′-Cyclic Azomethine Imine 1,3-Dipole with N -( o -Chloromethyl)aryl Amides

作者：Qiaomei Jin, Jian Zhang, Cuihua Jiang, Dongjian Zhang, Meng Gao, Shihe Hu · 发表于：The Journal of Organic Chemistry · 年份：2018 · DOI：10.1021/acs.joc.8b01055 · 被引用次数：52 · 研究领域：Synthesis and Catalytic Reactions、Catalytic C–H Functionalization Methods、Chemical Synthesis and Analysis

A [3 + 4] annulation of isatin N, N'-cyclic azomethine imine 1,3-dipole 1 with in situ-generated aza-oQMs has been established for the synthesis of spirooxindole seven-membered scaffolds. These highly functionalized scaffolds were assembled in moderate to good yields (up to 96% yield). The novel spirooxindole scaffolds displayed moderate antitumor activities, which represented promising lead compounds for antitumor drug discovery.