Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction

作者：Peipei Wang, Xiuqin Jia, Miao Zhang, Yanxiang Cao, Zhilian Zhao, Yi Shan, Qingfeng Ma, Tianyi Qian, Jingjuan Wang, Jie Lu, Kuncheng Li · 发表于：Frontiers in Neurology · 年份：2018 · DOI：10.3389/fneur.2018.00312 · 被引用次数：22 · 研究领域：Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications、Transcranial Magnetic Stimulation Studies

The mechanisms of motor functional recovery after pontine infarction (PI) remain unclear. Here, we assessed longitudinal changes in gray matter volume (GMV) and examined the relationship between GMV and clinical outcome. Fifteen patients with unilateral PI underwent magnetic resonance imaging and neurological exams five times during a period of 6 months. Another 15 healthy participants were enrolled as the normal control (NC) group and were examined with the same protocol. The MR exam included routine protocol and a 3D T1-weighted magnetization-prepared rapid acquisition gradient echo scan. Changes in GMV were assessed using voxel-based morphometry. Furthermore, the correlations between GMV changes in regions of interest and clinical scores were assessed. Compared with NCs, the decreased GMVs in the contralateral uvula of cerebellum and the ipsilateral tuber of cerebellum were detected at third month after stroke onset. At the sixth month after stroke onset, the decreased GMVs were detected in the contralateral culmen of cerebellum, putamen, as well as in the ipsilateral tuber/tonsil of cerebellum. Compared with NC, the PI group exhibited significant increases in GMV at each follow-up time point relative to stroke onset. Specifically, the significant GMV increase was found in the ipsilateral middle frontal gyrus and ventral anterior nucleus of thalamus at second week after stroke onset. At first month after stroke onset, the increased GMVs in the ipsilateral middle temporal g...