Identification and characterization of atypical porcine pestivirus genomes in newborn piglets with congenital tremor in China

作者：Hanqin Shen, Xiangcong Liu, Pengfei Zhang, Lei Wang, Yanling Liu, Leyi Zhang, Pengshuai Liang, Changxu Song · 发表于：Journal of Veterinary Science · 年份：2018 · DOI：10.4142/jvs.2018.19.3.468 · 被引用次数：34 · 研究领域：Animal Disease Management and Epidemiology、Animal Virus Infections Studies、Virus-based gene therapy research

Recently, a novel atypical porcine pestivirus (APPV) in pig was reported. In this study, two APPV strains, APPV-China/GZ01/2016 (GZ01) and APPV-China/GD-SD/2016 (GD-SD), were identified in two newborn piglet herds with congenital tremor from China. The open reading frame of the two strains shared an 83.5% nucleotide identity. Phylogenetically, the APPV strains were placed into two groups: GZ01 belonged to group I and GD-SD belonged to group II. A high viral load was detected in the cerebellum (quantification cycles ＜ 26). Further studies should be carried out to thoroughly elucidate the development of congenital tremors caused by APPV.