Clinical features and risk factors of neurological involvement in Sjögren’s syndrome

作者：Wenjing Ye, Siyan Chen, Xinshi Huang, Wei Qin, Ting Zhang, Xiaofang Zhu, Xiaochun Zhu, Chongxiang Lin, Xiaobing Wang · 发表于：BMC Neuroscience · 年份：2018 · DOI：10.1186/s12868-018-0427-y · 被引用次数：39 · 研究领域：Salivary Gland Disorders and Functions、Systemic Lupus Erythematosus Research、Liver Diseases and Immunity

BACKGROUND: To investigated distinct manifestations of Sjögren's syndrome (SS) patients with neurological complications and the potential risk factors associated with neurological complications in SS, and to produce a disease evaluation and neurological involvement prediction for SS. METHODS: 566 patients who fulfilled the 2002 classification criteria for SS from the Rheumatology Department of the First Affiliated Hospital of Wenzhou Medical University were included in the cross-sectional study. Clinical, immunological and histological characteristics were surveyed, and potential risk factors for neurological complications were examined by multivariate analysis. RESULTS: Among 566 SS patients, 184 (32.5%) patients had neurological involvement, with more than 10% got limbs pain, limbs numbness and cerebral infarction, respectively. Of these 184 SS patients with neurological complications, secondary SS (sSS) patients had a higher prevalence of peripheral nervous system (PNS) involvement than primary SS (pSS) patients (31.1 vs. 19%). And sSS patients showed higher total ESSPRI score and higher prevalence of xerostomia and low C3, C4 levels with more liver, articular involvement and saliva gland atrophy, and more severe lymphocyte infiltration in salivary glands than pSS patients. As for the specific factors associated with neurological involvement, low C3 level were found to be significant in pSS or sSS patients who were younger 50 year old, and ANA positivity, cardiac involveme...