Noninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel

作者：Mu Li, Xiangmei Liu, Lei Tan, Zhenduo Cui, Xianjin Yang, Zhaoyang Li, Yufeng Zheng, Kwk Yeung, Paul K. Chu, Shuilin Wu · 发表于：Biomaterials Science · 年份：2018 · DOI：10.1039/c8bm00499d · 被引用次数：218 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Electrospun Nanofibers in Biomedical Applications

Bacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99.80% and 99.94% against Staphylococcus aureus and Escherichia coli within 10 min, respectively. The excellent performance stems from the combined effects of hyperthermia, radical oxygen species, and released copper ions produced during NIR irradiation of CuS NPs. Moreover, the released copper ions stimulate fibroblast proliferation and angiogenesis and the intrinsic volume transition of the hydrogel composed of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) controls the release rate of copper ions during NIR light irradiation leading to both antibacterial effects and skin tissue regeneration.