Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

作者：Joseph A. Fraietta, Christopher L. Nobles, Morgan A. Sammons, Stefan M. Lundh, Shannon A. Carty, Tyler J. Reich, Alexandria P. Cogdill, Jennifer J. D. Morrissette, Jamie E. DeNizio, Shantan G. Reddy, Young Sun Hwang, Mercy Gohil, Irina M. Kulikovskaya, Farzana Nazimuddin, Minnal Gupta, Fang Chen, J.K. Everett, Katherine A. Alexander, Enrique Lin-Shiao, Marvin H. Gee, Xiaojun Liu, Regina M. Young, David E Ambrose, Yan Wang, Jun Xu, Martha S. Jordan, Katherine T. Marcucci, Bruce L. Levine, K. Christopher García, Yangbing Zhao, Michael D. Kalos, David Porter, Rahul M. Kohli, Simon Francis Lacey, Shelley L. Berger, Frederic D. Bushman, Carl H. June, Jan Joseph Melenhorst · 发表于：Nature · 年份：2018 · DOI：10.1038/s41586-018-0178-z · 被引用次数：879 · 研究领域：CAR-T cell therapy research、Immune Cell Function and Interaction、CRISPR and Genetic Engineering