Pseudomonas aeruginosa transcriptome during human infection

作者：Daniel M. Cornforth, Justine L. Dees, Carolyn B. Ibberson, Holly Huse, Inger Hee Mabuza Mathiesen, Klaus Kirketerp‐Møller, Randy D. Wolcott, Kendra P. Rumbaugh, Thomas Bjarnsholt, Marvin Whiteley · 发表于：Proceedings of the National Academy of Sciences · 年份：2018 · DOI：10.1073/pnas.1717525115 · 被引用次数：295 · 研究领域：Bacterial biofilms and quorum sensing、Bacterial Genetics and Biotechnology、Bacteriophages and microbial interactions

Significance Microbiologists typically use laboratory systems to study the bacteria that infect humans. Over time, this has created a gap between what researchers understand about bacteria growing in the laboratory and those growing in humans. It is well-known that the behavior of bacteria is shaped by their environment, but how this behavior differs in laboratory models compared with human infections is poorly understood. We compared transcription data from a variety of human infections with data from a range of in vitro samples. We found important differences in expression of genes involved in antibiotic resistance, cell–cell communication, and metabolism. Understanding the bacterial expression patterns in human patients is a necessary step toward improved therapy and the development of more accurate laboratory models.