An ingestible bacterial-electronic system to monitor gastrointestinal health

作者：Mark Mimee, Phillip M. Nadeau, Alison M. Hayward, Sean Carim, Sarah Flanagan, Logan Andrew Jerger, Joy E. Collins, Shane McDonnell, Richard Swartwout, Robert J. Citorik, Vladimir Bulović, Róbert Langer, Giovanni Battista Traverso, Anantha P. Chandrakasan, Timothy K. Lu · 发表于：Science · 年份：2018 · DOI：10.1126/science.aas9315 · 被引用次数：616 · 研究领域：Biosensors and Analytical Detection、Molecular Communication and Nanonetworks、Microfluidic and Bio-sensing Technologies

Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease.