Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017

作者：Thibault Poncin, S. Fouéré, Aymeric Braille, François Caméléna, Myriem Agsous, Cécile Bébéar, Sylvain Kumanski, Florence Lot, Séverine Mercier‐Delarue, Ndeindo Ndeikoundam Ngangro, Maud Salmona, Nathalie Schnepf, Julie Timsit, Magnus Unemo, Béatrice Berçot · 发表于：Eurosurveillance · 年份：2018 · DOI：10.2807/1560-7917.es.2018.23.21.1800264 · 被引用次数：106 · 研究领域：Reproductive tract infections research、Syphilis Diagnosis and Treatment、Bacterial Infections and Vaccines

We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST 1903 , NG-MAST ST 3435 , NG-STAR 233 , and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.